I roto i te rongoā i ngā tūroro e pāngia ana e te mate manawa, me whakakapi ngā wāhanga kua pakaru, kua ārai rānei o te pūnaha manawa, mā te whakawhitinga ā-roto, mā te whakamahi rānei i ngā rauemi biocompatible. Ehara i te mea ko te whakawhitinga ā-roto anake te mea e hiahiatia ana kia taea e te tūroro te whakarato i tētahi wāhanga hauora hei whakakapi, engari me kore hoki e pā te whakakapinga ki te oranga noa o te tūroro, nō reira he tino teitei ngā whakaritenga. Mō te nuinga o ngā tūroro e pāngia ana e te mate manawa, he maha ngā wā ka whakamahia e ngā tākuta ngā uaua toto horihori hei whakaoti i te mahi pokanga.

He maha ngā rauemi me ngā tikanga e hangaia ai ngā oko toto horihori. Nō nā tata nei, i whatuhia e tētahi rōpū kairangahau mai i NC State me CWRU tētahi oko toto horihori mā te whakakotahi i ngā muka collagen me te waikawa polylactic.

Ko te mea hou mō tēnei oko toto horihori koia ēnei:

(1) Ka taea e ngā wāhanga korarane i roto i ngā muka korarane te whakanui ake i te piri o ngā pūtau tuatahi mā te 10 ngā wā. I muri i tētahi wā whakatipu, ko te maha o ngā pūtau e kohikohi ana me te tipu haere he 3.2 ngā wā teitei ake i te maha o ngā oko toto horihori i hangaia mai i te muka PLA anake, he tere te pānga endothelialization.

(2) Ka taea e te muka waikawa polylactic te whakarato i te kaha miihini me te pumau hanganga, me te mahi hei hanganga, e whai hua ana ki te hanga tere-tere o tēnei oko toto horihori, kia tutuki ai te ahumahi.

(3) Ko ngā oko toto horihori whiri i whakaatuhia he kaha pakaru pai rawa atu (1.89±0.43 MPa) me te kaha tiaki tuitui (10.86±0.49 N), ā, ko te taumata pēhanga (3.98± 1.94% / 100 mmHg) he rite ki te taumata pēhanga o ngā uaua ngakau i raro i te pēhanga toto noa (3.8± 0.3% / 100 mmHg), e whakaatu ana i te pai o te urutau.

(4) He rite te ngāwari o te hanganga whatu porowhita ki te uaua o te ngākau tūturu, ā, ka taea te whānui me te whakawhāiti.

Ehara tēnei momo mate toto horihori i te mea he mea tāpiri tūturu, ā, ka taea te tautoko i te whakatikatika i ngā toto i te wā tuatahi o te whakaurunga, ka taea te pakaru me te mimiti e te tinana i te mutunga. Ko te raruraru matua, e ngana tonu ana te tīma ki te whakakore, ko te nui ake o ngā pūwero hanganga o te toto e taea ai te rere o te toto ki waho.

Ko te taitara o te mahi a te tīma ko "He hononga toto ranu e whakamahi ana i ngā āhuatanga miihini pai o ngā muka hangai me te mahi koiora o ngā miro Collagen," i whakaputaina i roto i te Pūtaiao Rauemi me te Hangarau: C.

Ko te hononga taketake: https://doi.org/10.1016/j.msec.2020.111418